Article date: March 1983
By: R. Soares Moura, J. Socrates Lima in Volume 78, Issue 3, pages 449-451
Disopyramide produces a contraction of the isolated aortic ring of the rat which is graded, develops slowly, and has a time course similar to the tonic phase of the noradrenaline response. This effect is not modified by α‐adrenoceptor blockade (yohimbine) but is completely abolished by a Ca2+ antagonist (verapamil) or by removal of Ca2+ from the bathing solution. These results indicate that, in the rat aorta, disopyramide has a vasoconstrictor effect dependent on Ca2+ influx across the vascular smooth muscle membrane.
DOI: 10.1111/j.1476-5381.1983.tb08803.x
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