Article date: August 1982
By: H.W. MITCHELL in Volume 76, Issue 4, pages 527-529
Arachidonic acid caused larger contractions in indomethacin‐treated guinea‐pig trachea than in control tracheae.
No change in contractions was obtained in tracheae treated with 5, 8, 11, 14, eicosatetraynoic acid (ETYA 10 μm).
ETYA (100 μm) blocked the effect of indomethacin on arachidonic acid‐induced responses. Likewise BW 755c (113 μm) reversed the effect of indomethacin.
The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin.
Arachidonic acid caused larger contractions in indomethacin‐treated guinea‐pig trachea than in control tracheae.
No change in contractions was obtained in tracheae treated with 5, 8, 11, 14, eicosatetraynoic acid (ETYA 10 μm).
ETYA (100 μm) blocked the effect of indomethacin on arachidonic acid‐induced responses. Likewise BW 755c (113 μm) reversed the effect of indomethacin.
The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin.
DOI: 10.1111/j.1476-5381.1982.tb09250.x
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