Article date: August 1982
By: ROY G. GOLDIE, JAMES W. PATERSON, JANET L. WALE in Volume 76, Issue 4, pages 523-526
Responses to (±)‐isoprenaline (Iso), (−)‐adrenaline (Adr) and (−)‐noradrenaline (NA) were compared in isolated preparations of human and porcine lung parenchyma strip.
The order of relaxant potencies of these catecholamines in both human and porcine lung parenchyma was Iso > Adr > NA (1:0.24:0.01, human; 1:0.21:0.01, pig). These results suggest that β2‐adrenoceptors predominate in both types of lung parenchyma strip.
pA2 values for the β‐adrenoceptor antagonist, propranolol (non‐selective), with Iso as the agonist, in human and porcine lung strips were 7.84 and 7.83 respectively and for atenolol were 6.50 and 5.35 respectively. Taken as a whole, results indicate the existence of an apparently homogeneous population of β2‐adrenoceptors in porcine parenchyma strip, while both β1 and β2‐adrenoceptors were revealed in human lung parenchyma.
Responses to (±)‐isoprenaline (Iso), (−)‐adrenaline (Adr) and (−)‐noradrenaline (NA) were compared in isolated preparations of human and porcine lung parenchyma strip.
The order of relaxant potencies of these catecholamines in both human and porcine lung parenchyma was Iso > Adr > NA (1:0.24:0.01, human; 1:0.21:0.01, pig). These results suggest that β2‐adrenoceptors predominate in both types of lung parenchyma strip.
pA2 values for the β‐adrenoceptor antagonist, propranolol (non‐selective), with Iso as the agonist, in human and porcine lung strips were 7.84 and 7.83 respectively and for atenolol were 6.50 and 5.35 respectively. Taken as a whole, results indicate the existence of an apparently homogeneous population of β2‐adrenoceptors in porcine parenchyma strip, while both β1 and β2‐adrenoceptors were revealed in human lung parenchyma.
DOI: 10.1111/j.1476-5381.1982.tb09249.x
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