Orally administered 2,3‐dimercaptopropane sodium sulphonate (DMPS, Dimaval) reduced the concentration of gold in rats treated with Auro‐Detoxin and increased the urinary excretion of the metal.
In a long‐term experiment, DMPS decreased significantly the concentration of gold in the kidneys and in the skin and increased it in plasma.
DMPS appears to be of interest as a possible antidote to gold, which could replace the more toxic 2,3‐dimercaptopropanol (BAL).
Orally administered 2,3‐dimercaptopropane sodium sulphonate (DMPS, Dimaval) reduced the concentration of gold in rats treated with Auro‐Detoxin and increased the urinary excretion of the metal.
In a long‐term experiment, DMPS decreased significantly the concentration of gold in the kidneys and in the skin and increased it in plasma.
DMPS appears to be of interest as a possible antidote to gold, which could replace the more toxic 2,3‐dimercaptopropanol (BAL).
DOI: 10.1111/j.1476-5381.1980.tb10850.x
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