Article date: April 1980
By: ROGER ANWYL, TOSHIO NARAHASHI in Volume 68, Issue 4, pages 611-615
The action of C5‐decahydrohistrionicotoxin (C5‐HTX) has been investigated on the extrajunctional acetylcholine (ACh) receptors of denervated rat muscle.
C5‐HTX causes both a rapid and slow reduction in amplitude of iontophoretic ACh potentials evoked at all frequencies from the extrajunctional receptors.
C5‐HTX also causes a time‐dependent inhibition of the iontophoretic potentials evoked at frequencies greater than 0.02 Hz. This inhibition was observed either alone or superimposed upon desensitization, and may be caused by a similar mechanism to desensitization.
The action of C5‐decahydrohistrionicotoxin (C5‐HTX) has been investigated on the extrajunctional acetylcholine (ACh) receptors of denervated rat muscle.
C5‐HTX causes both a rapid and slow reduction in amplitude of iontophoretic ACh potentials evoked at all frequencies from the extrajunctional receptors.
C5‐HTX also causes a time‐dependent inhibition of the iontophoretic potentials evoked at frequencies greater than 0.02 Hz. This inhibition was observed either alone or superimposed upon desensitization, and may be caused by a similar mechanism to desensitization.
DOI: 10.1111/j.1476-5381.1980.tb10851.x
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