Article date: October 1972
By: M. W. PARKES, JENNIFER C. PARKS in Volume 46, Issue 2, pages 315-323
. The duration of the effect of a single large dose of hyoscine, in reducing the salivary response of mice to pilocarpine, was established as less than 66 hours.
. Supersensitivity was observed, after daily oral dosing with hyoscine, in the increased salivation of mice in response to pilocarpine injected at least 66 h after withdrawing hyoscine.
. The minimum duration of pretreatment with hyoscine that resulted in supersensitivity was 5 days. The daily dose was more effective if divided.
. The period after withdrawal for which supersensitivity could be detected was 6 days.
. The maximum salivary response to pilocarpine was increased by chronic hyoscine pretreatment.
. The antagonism of a single dose of hyoscine to pilocarpine salivation, as expressed by the dose‐ratio of pilocarpine, was not altered by chronic hyoscine pre‐treatment.
. The duration of the effect of a single large dose of hyoscine, in reducing the salivary response of mice to pilocarpine, was established as less than 66 hours.
. Supersensitivity was observed, after daily oral dosing with hyoscine, in the increased salivation of mice in response to pilocarpine injected at least 66 h after withdrawing hyoscine.
. The minimum duration of pretreatment with hyoscine that resulted in supersensitivity was 5 days. The daily dose was more effective if divided.
. The period after withdrawal for which supersensitivity could be detected was 6 days.
. The maximum salivary response to pilocarpine was increased by chronic hyoscine pretreatment.
. The antagonism of a single dose of hyoscine to pilocarpine salivation, as expressed by the dose‐ratio of pilocarpine, was not altered by chronic hyoscine pre‐treatment.
DOI: 10.1111/j.1476-5381.1972.tb06876.x
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