. The oestrogenic properties of four triphenylethylene compounds were compared. They can be listed as follows in order of their oestrogenic potency: 1‐[p‐(β‐diethylaminoethoxy)‐phenyl]‐2‐nitro‐1,2‐diphenylethylene (E.I.P.W. 111) > clomiphene > 1‐[p‐(β‐dimethylaminoethoxy)‐phenyl]‐2‐nitro‐1,2‐diphenylethylene (E.I.P.W. 113)>1‐[p‐(β‐diethylaminoethoxy)‐phenyl]‐1,2‐diphenylethylene (E.I.P.W. 103). The oestrogenic potency of compound E.I.P.W. 111 was found to be about 1/10th of that of oestradiol.
. Compound E.I.P.W. 111 is partially antioestrogenic but not progesteronic in nature. It has no androgenic effect.
. The oestrogenic properties of four triphenylethylene compounds were compared. They can be listed as follows in order of their oestrogenic potency: 1‐[p‐(β‐diethylaminoethoxy)‐phenyl]‐2‐nitro‐1,2‐diphenylethylene (E.I.P.W. 111) > clomiphene > 1‐[p‐(β‐dimethylaminoethoxy)‐phenyl]‐2‐nitro‐1,2‐diphenylethylene (E.I.P.W. 113)>1‐[p‐(β‐diethylaminoethoxy)‐phenyl]‐1,2‐diphenylethylene (E.I.P.W. 103). The oestrogenic potency of compound E.I.P.W. 111 was found to be about 1/10th of that of oestradiol.
. Compound E.I.P.W. 111 is partially antioestrogenic but not progesteronic in nature. It has no androgenic effect.
DOI: 10.1111/j.1476-5381.1972.tb06877.x
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