Inhibitory and stimulatory effects of secretin on gastric secretion in conscious rats

Article date: September 1972

By: IRENE JOHANSSON, L. LUNDELL, S. E. SVENSSON in Volume 46, Issue 1, pages 94-100

. The effect of pure secretin on gastrin‐induced secretion has been studied in conscious rats with Pavlov or Heidenhain pouches.

. Rapid intravenous injection of secretin did not inhibit a plateau secretion of acid in the Heidenhain pouch, but infusion of the same amount of secretin over two hours inhibited secretion in both Heidenhain and Pavlov pouches.

. A rapid intravenous injection of secretin before the onset of gastrin infusion enhanced the acid secretory response to gastrin in both types of pouches.

. Secretin stimulated pepsin secretion.

. The effect of pure secretin on gastrin‐induced secretion has been studied in conscious rats with Pavlov or Heidenhain pouches.

. Rapid intravenous injection of secretin did not inhibit a plateau secretion of acid in the Heidenhain pouch, but infusion of the same amount of secretin over two hours inhibited secretion in both Heidenhain and Pavlov pouches.

. A rapid intravenous injection of secretin before the onset of gastrin infusion enhanced the acid secretory response to gastrin in both types of pouches.

. Secretin stimulated pepsin secretion.

DOI: 10.1111/j.1476-5381.1972.tb06852.x

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