Prevention by the cannabinoid antagonist, SR141716A, of cannabinoid‐mediated blockade of long‐term potentiation in the rat hippocampal slice

Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (−)−11‐OH‐Δ⁸–dimethylheptyl tetrahydrocannabinol (HU‐210) (100 nM) prevented the induction of long‐term potentiation (LTP). Slices co‐incubated with both³HU‐210 (100 nM) and the cannabinoid antagonist, SR141716A (100 nM), exhibited tetanically induced LTP, comparable to control slices. Intriguingly, co‐incubation with³HU‐210 and SR141716A prevented the induction of the early, short‐term phase of LTP.

DOI: 10.1111/j.1476-5381.1995.tb15889.x

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