Article date: July 1995
By: V. Bauer, V.V. Rekalov, I. Juranek, D. Gergel, P. Bohov, in Volume 115, Issue 6, pages 871-874
The effects of nifedipine (Nif) and its illuminated nitroso product nitrosopine (NTP) were investigated on lipid peroxidation, KC1 elevated smooth muscle tension, and ionic currents of single smooth muscle cells.
Illumination of Nif at 400–700 nm within 24–48 h changed it completely to a potent antioxidant, NTP.
Nif relaxed the KCl‐induced contractions of guinea‐pig taenia caeci and rat aorta and reduced the amplitude of the evoked inward Ca2+ current of taenia caeci cells in a concentration‐dependent manner. NTP (up to 100 μm) was ineffective in this respect. Pretreatment by NTP (10 μm) did not affect the actions of Nif.
The evidence suggests that NTP, generated by day‐light illumination from Nif, exerts antioxidant activity but is devoid of voltage‐dependent Ca2+ channel (VDC) blocking property and does not interfere with the action of Nif on the smooth muscle cell membrane VDC.
The effects of nifedipine (Nif) and its illuminated nitroso product nitrosopine (NTP) were investigated on lipid peroxidation, KC1 elevated smooth muscle tension, and ionic currents of single smooth muscle cells.
Illumination of Nif at 400–700 nm within 24–48 h changed it completely to a potent antioxidant, NTP.
Nif relaxed the KCl‐induced contractions of guinea‐pig taenia caeci and rat aorta and reduced the amplitude of the evoked inward Ca2+ current of taenia caeci cells in a concentration‐dependent manner. NTP (up to 100 μm) was ineffective in this respect. Pretreatment by NTP (10 μm) did not affect the actions of Nif.
The evidence suggests that NTP, generated by day‐light illumination from Nif, exerts antioxidant activity but is devoid of voltage‐dependent Ca2+ channel (VDC) blocking property and does not interfere with the action of Nif on the smooth muscle cell membrane VDC.
DOI: 10.1111/j.1476-5381.1995.tb15890.x
View this article