Article date: September 1987
By: RO Day, S Lam, P Paull, D Wade, in Volume 24, Issue 3, pages 323-328
1 Twelve healthy volunteers received a single oral dose of tenoxicam 20 mg on six occasions separated by 3 weeks. 2 The six occasions were: fasted overnight; postprandial; fasting and 15 ml aluminium hydroxide gel; postprandial and 15 ml aluminium hydroxide gel; fasting and 15 ml aluminium and magnesium hydroxide gel; postprandial and 15 ml aluminium and magnesium hydroxide gel. 3 Twenty plasma samples were collected over 15 days following dosing with tenoxicam. 4 The following kinetic parameters for plasma tenoxicam were compared: peak concentrations, time taken to reach peak concentrations, area under the plasma concentration‐time curve (AUC) and half‐life of elimination. 5 Food lengthened the time taken to reach peak tenoxicam concentrations (5.82 +/‐ 4.6 vs 1.84 +/‐ 1.0 h in the fasting state; P less than 0.02) and marginally reduced the peak concentrations achieved. AUC was not affected by any of the different regimens. 6 These effects of food on tenoxicam bioavailability are unlikely to be of clinical significance during chronic dosing with the drug.
DOI: 10.1111/j.1365-2125.1987.tb03176.x
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