Article date: September 1987
By: M Rowland, SK Gupta, in Volume 24, Issue 3, pages 329-334
1 Freeman et al. (1984) evoked enzyme induction to explain the lower plasma concentration of cyclosporin following phenytoin co‐ administration in man. 2 We have examined the whole blood concentration data of two metabolites of cyclosporin, as well as unchanged drug, all measured by h.p.l.c., associated with the above mentioned study. 3 Phenytoin produced no significant effect on either the terminal half‐ life of both metabolites or the ratio of area under the concentration‐ time curve of metabolite to parent drug. 4 These data strongly suggest that phenytoin reduces the absorption of cyclosporin; they do not generally support the idea that phenytoin induces cyclosporin metabolism.
DOI: 10.1111/j.1365-2125.1987.tb03177.x
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