Article date: October 1974
By: R.J. FLANAGAN, A. RICHENS, in Volume 1, Issue 5, pages 409-412
The plasma half‐life of antipyrine was estimated overnight in four healthy volunteers on two separate occasions, one during i.v. infusion of hydrocortisone (3 mg/h) and the second during an infusion of normal saline.
The plasma fluorogenic corticosteroid concentration averaged 12.5 μg/100 ml during saline infusion, increasing to 20.1 μg/100 ml during hydrocortisone infusion.
The mean antipyrine half‐life increased from 9.7 h during saline infusion to 12.6 h during hydrocortisone infusion.
No consistent change was found in the apparent volume of distribution or urinary excretion of antipyrine, or of the urinary excretion of D‐glucaric acid.
The stimulation by hydrocortisone of antipyrine metabolism demonstrated by other workers has not been found.
The plasma half‐life of antipyrine was estimated overnight in four healthy volunteers on two separate occasions, one during i.v. infusion of hydrocortisone (3 mg/h) and the second during an infusion of normal saline.
The plasma fluorogenic corticosteroid concentration averaged 12.5 μg/100 ml during saline infusion, increasing to 20.1 μg/100 ml during hydrocortisone infusion.
The mean antipyrine half‐life increased from 9.7 h during saline infusion to 12.6 h during hydrocortisone infusion.
No consistent change was found in the apparent volume of distribution or urinary excretion of antipyrine, or of the urinary excretion of D‐glucaric acid.
The stimulation by hydrocortisone of antipyrine metabolism demonstrated by other workers has not been found.
DOI: 10.1111/j.1365-2125.1974.tb00278.x
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