Article date: October 1974
By: H.E. BARBER, T.N. CALVEY, K. MUIR, A. HART, in Volume 1, Issue 5, pages 405-408
The concentration of oxytetracycline in plasma was studied by microbiological assay after oral administration of four different preparations of oxytetracycline dihydrate tablets.
There were statistically significant differences in biological availability between the four preparations, as assessed by the peak plasma level, the area under the plasma concentration‐time curve, or the cumulative fraction of the dose excreted in urine at 405 minutes. In contrast, differences between the subjects were not statistically significant.
The differences in biological availability were not predictably related to the in vitro dissolution of the tablets.
The concentration of oxytetracycline in plasma was studied by microbiological assay after oral administration of four different preparations of oxytetracycline dihydrate tablets.
There were statistically significant differences in biological availability between the four preparations, as assessed by the peak plasma level, the area under the plasma concentration‐time curve, or the cumulative fraction of the dose excreted in urine at 405 minutes. In contrast, differences between the subjects were not statistically significant.
The differences in biological availability were not predictably related to the in vitro dissolution of the tablets.
DOI: 10.1111/j.1365-2125.1974.tb00277.x
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