Article date: November 1982
By: P.F. MORGAN, T.W. STONE in Volume 77, Issue 3, pages 525-529
Ethylenediamine, 31.6–1000 mg/kg intraperitoneally, inhibited the convulsive effects of pentylenetetrazol, 100 mg/kg (i.p.) in mice.
Ethylenediamine, 100–1000 mg/kg (i.p.) increased the convulsion threshold to the intravenous infusion of three convulsants in the order pentylenetetrazol > bicuculline > strychnine.
The benzodiazepine antagonist Ro15–1788, 10 mg/kg (i.p.), significantly inhibited the anticonvulsant action of diazepam, 50 μg/kg, but not ethylenediamine, 1000 mg/kg.
These results clearly indicate that ethylenediamine has anticonvulsant properties and are consistent with the hypothesis that ethylenediamine is a γ‐aminobutyric acid (GABA)‐mimetic.
Ethylenediamine, 31.6–1000 mg/kg intraperitoneally, inhibited the convulsive effects of pentylenetetrazol, 100 mg/kg (i.p.) in mice.
Ethylenediamine, 100–1000 mg/kg (i.p.) increased the convulsion threshold to the intravenous infusion of three convulsants in the order pentylenetetrazol > bicuculline > strychnine.
The benzodiazepine antagonist Ro15–1788, 10 mg/kg (i.p.), significantly inhibited the anticonvulsant action of diazepam, 50 μg/kg, but not ethylenediamine, 1000 mg/kg.
These results clearly indicate that ethylenediamine has anticonvulsant properties and are consistent with the hypothesis that ethylenediamine is a γ‐aminobutyric acid (GABA)‐mimetic.
DOI: 10.1111/j.1476-5381.1982.tb09327.x
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