Article date: June 1982
By: B. BELLEAU, B.G. BENFEY, C. MELCHIORRE, M. MONTAMBAULT in Volume 76, Issue 2, pages 253-257
The activity of the irreversible α‐adrenoceptor blocking drug, benextramine, was determined in human platelets.
Compared to its postsynaptic and presynaptic α‐adrenoceptor blocking potency, benextramine had a very low potency as an antagonist of adrenaline‐induced platelet aggregation.
The results confirm the previous observation with the irreversible α‐adrenoceptor blocking drug, phenoxybenzamine, that platelet α‐adrenoceptors differ from postsynaptic and presynaptic α‐adrenoceptors.
The activity of the irreversible α‐adrenoceptor blocking drug, benextramine, was determined in human platelets.
Compared to its postsynaptic and presynaptic α‐adrenoceptor blocking potency, benextramine had a very low potency as an antagonist of adrenaline‐induced platelet aggregation.
The results confirm the previous observation with the irreversible α‐adrenoceptor blocking drug, phenoxybenzamine, that platelet α‐adrenoceptors differ from postsynaptic and presynaptic α‐adrenoceptors.
DOI: 10.1111/j.1476-5381.1982.tb09214.x
View this article