Article date: August 1981
By: AMOS D. KORCZYN, MEIR ROCK in Volume 73, Issue 4, pages 807-810
Morphine‐induced mydriasis in mice is antagonized by nalorphine, levallorphan and naloxone in a dose‐dependent manner.
The relative potency of the three agents is 10: 56: 134 respectively, thus being in accordance with other tests of narcotic antagonism. Naloxone has the shortest duration of action.
When injected into naive animals, nalorphine (but not levallorphan or naloxone) produces a slight mydriasis.
Measurement of the diameter of the pupil in mice seems to be a precise, simple and rapid test for studying narcotic antagonist as well as agonist action and has several advantages over standard methods used for this purpose.
Morphine‐induced mydriasis in mice is antagonized by nalorphine, levallorphan and naloxone in a dose‐dependent manner.
The relative potency of the three agents is 10: 56: 134 respectively, thus being in accordance with other tests of narcotic antagonism. Naloxone has the shortest duration of action.
When injected into naive animals, nalorphine (but not levallorphan or naloxone) produces a slight mydriasis.
Measurement of the diameter of the pupil in mice seems to be a precise, simple and rapid test for studying narcotic antagonist as well as agonist action and has several advantages over standard methods used for this purpose.
DOI: 10.1111/j.1476-5381.1981.tb08732.x
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