Article date: February 1980
By: DEBORAH K. HYSLOP, DUNCAN P. TAYLOR in Volume 71, Issue 2, pages 359-361
The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]‐quinuclidinyl benzilate in vitro was used for comparing atropine‐like effects. Trazodone was found to have essentially no activity at the muscarinic acetylcholine binding site in comparison to the tricyclic antidepressants.
DOI: 10.1111/j.1476-5381.1980.tb10947.x
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