Article date: October 1978
By: C.R. BENEDICT, M. FILLENZ, CLARE STANFORD in Volume 64, Issue 2, pages 305-309
A method is described for repeated sampling of plasma noradrenaline (NA) in freely moving rats. Na concentration does not change during the day or after adrenalectomy.
Exogenous NA has a half‐life of 1.5 min; drugs which block neuronal and extra‐neuronal uptake lengthen this to 6.3 min.
Swim‐stress leads to a steep rise followed by a rapid decline in plasma NA concentration.
This method of plasma NA sampling can serve as a measure of both steady and rapid changes in release rate over long periods of time.
A method is described for repeated sampling of plasma noradrenaline (NA) in freely moving rats. Na concentration does not change during the day or after adrenalectomy.
Exogenous NA has a half‐life of 1.5 min; drugs which block neuronal and extra‐neuronal uptake lengthen this to 6.3 min.
Swim‐stress leads to a steep rise followed by a rapid decline in plasma NA concentration.
This method of plasma NA sampling can serve as a measure of both steady and rapid changes in release rate over long periods of time.
DOI: 10.1111/j.1476-5381.1978.tb17305.x
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