Article date: April 1978
By: ROBERT D. KRELL in Volume 62, Issue 4, pages 519-528
Aerosol administration of ascaris antigen to the airways of ascaris‐hypersensitive dogs provoked increases in pulmonary resistance (Rp) and decreases in dynamic lung compliance (Cdyn). These changes in pulmonary mechanics were not inhibited by the histamine H1‐receptor antagonists, diphenhydramine or mepyramine.
Increases in Rp and decreases in Cdyn induced by a histamine aerosol were markedly or totally inhibited by comparable doses of these HI‐antihistamines.
Doses of antigen which produced pathophysiological pulmonary responses failed to produce a detectable histamine release from the cardiopulmonary system in vitio. Aerosol antigen provocation, equivalent to 5 to 9 times greater than that which produced substantial pathophysiological pulmonary responses, did cause histamine release in vivo.
The canine cardiopulmonary system showed only a modest ability to remove and/or degrade circulating histamine.
It is concluded that histamine may not play a major role in mediating the acute antigen‐induced bronchoconstriction in the ascaris‐hypersensitive dog.
Aerosol administration of ascaris antigen to the airways of ascaris‐hypersensitive dogs provoked increases in pulmonary resistance (Rp) and decreases in dynamic lung compliance (Cdyn). These changes in pulmonary mechanics were not inhibited by the histamine H1‐receptor antagonists, diphenhydramine or mepyramine.
Increases in Rp and decreases in Cdyn induced by a histamine aerosol were markedly or totally inhibited by comparable doses of these HI‐antihistamines.
Doses of antigen which produced pathophysiological pulmonary responses failed to produce a detectable histamine release from the cardiopulmonary system in vitio. Aerosol antigen provocation, equivalent to 5 to 9 times greater than that which produced substantial pathophysiological pulmonary responses, did cause histamine release in vivo.
The canine cardiopulmonary system showed only a modest ability to remove and/or degrade circulating histamine.
It is concluded that histamine may not play a major role in mediating the acute antigen‐induced bronchoconstriction in the ascaris‐hypersensitive dog.
DOI: 10.1111/j.1476-5381.1978.tb07756.x
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