The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug.
Oxypertine (4.4 × 10−10m to 2.6 × 10−5m) antagonized competitively the effects of noradrenaline (pA2 = 7.2), 5‐hydroxytryptamine (pA2 = 8.6) and dopamine (pA2 = 9.8).
Oxypertine (8.8 × 10 −9m to 2.6 × 10−5m) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine.
The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine.
Oxypertine failed to antagonize the responses to potassium chloride.
These findings are compared with the effects of other antidepressant drugs.
The isolated vas deferens of the rat was used to examine the peripheral action of oxypertine, a psychotropic‐anxiolytic drug.
Oxypertine (4.4 × 10−10m to 2.6 × 10−5m) antagonized competitively the effects of noradrenaline (pA2 = 7.2), 5‐hydroxytryptamine (pA2 = 8.6) and dopamine (pA2 = 9.8).
Oxypertine (8.8 × 10 −9m to 2.6 × 10−5m) antagonized the effects of low concentrations of acetylcholine and enhanced the contractions elicited by high concentrations of acetylcholine.
The contractions evoked by transmural stimulation of the vas deferens were reduced by oxypertine.
Oxypertine failed to antagonize the responses to potassium chloride.
These findings are compared with the effects of other antidepressant drugs.
DOI: 10.1111/j.1476-5381.1978.tb07755.x
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