Article date: July 1977
By: JEN‐TZAW HUANG, ISABEL J. WAJDA in Volume 60, Issue 3, pages 363-367
1 Choroid plexus obtained from the lateral ventricles of the rat actively accumulated homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA).
2 Morphine 5 × 10−6 M to 5 × 10−4 M potentiated 5‐HIAA accumulation but did not affect HVA accumulation. Levorphanol and dextrorphan had little effect.
3 Naloxone at high concentrations inhibited both HVA and 5‐HIAA accumulation.
4 Glutamic acid, glycine, and arginine also decreased 5‐HIAA accumulation, but lysine, tryptophan, and aspartic acid had no effect.
5 Probenecid, naloxone, arginine, glycine, and tryptophan blocked the increase of 5‐HIAA accumulation induced by morphine.
6 Acute or chronic morphine treatment did not increase the accumulation of 5‐HIAA.
7 These results suggest that the increase of 5‐HIAA or HVA in brain by morphine is not due to the inhibition of the elimination of these metabolites from the choroid plexus.
DOI: 10.1111/j.1476-5381.1977.tb07509.x
View this article