Article date: July 1977
By: M. MAUREEN DALE in Volume 60, Issue 3, pages 441-444
1 The effects of the H2‐receptor antagonist, metiamide, on two types of cell‐mediated immune response in vivo was investigated in the guinea‐pig, in a test of the hypothesis that H2‐receptor antagonists would result in ‘runaway’ unregulated hypersensitivity reactions.
2 Metiamide in doses of 5 mg‐125 mg/kg given by 6‐hourly injection during sensitization and challenge did not modify the delayed hypersensitivity reaction to tuberculin.
3 Metiamide in doses of 25‐125 mg/kg given by injection, 6‐hourly throughout sensitization to dinitrofluorobenzene (DNFB) and subsequent challenge six days later, did not modify the contact sensitivity reaction to DNFB.
4 It is concluded that metiamide, given during these cell‐mediated immune reactions in the guinea‐pig, does not enhance cell‐mediated hypersensitivity responses.
DOI: 10.1111/j.1476-5381.1977.tb07520.x
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