Article date: April 1976
By: O. CARRIER, R.K. HESTER in Volume 56, Issue 4, pages 449-455
Four hours after reserpine, rabbit aortic strips were supersensitive to acetylcholine, isoprenaline and noradrenaline. The threshold concentration of the drugs necessary to induce a response was less and the maximum tension developed by the tissues was greater than in control strips.
Reserpine‐treatment potentiated the contractile responses to CaCl2.
Reserpine‐treatment resulted in an increase in calcium uptake and an increase in the slow component of 45Ca2+ efflux.
After resperine‐treatment, the rate of relaxation from a potassium‐induced contraction was decreased.
It is concluded that reserpine‐induced supersensitivity is related to an enhanced ability of the tissue to retain and utilize calcium.
Four hours after reserpine, rabbit aortic strips were supersensitive to acetylcholine, isoprenaline and noradrenaline. The threshold concentration of the drugs necessary to induce a response was less and the maximum tension developed by the tissues was greater than in control strips.
Reserpine‐treatment potentiated the contractile responses to CaCl2.
Reserpine‐treatment resulted in an increase in calcium uptake and an increase in the slow component of 45Ca2+ efflux.
After resperine‐treatment, the rate of relaxation from a potassium‐induced contraction was decreased.
It is concluded that reserpine‐induced supersensitivity is related to an enhanced ability of the tissue to retain and utilize calcium.
DOI: 10.1111/j.1476-5381.1976.tb07457.x
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