Article date: December 1973
By: M. N. GHOSH, S. PARVATHY in Volume 49, Issue 4, pages 658-661
When food intake in fasted male rats was recorded daily for two consecutive 2 h periods it revealed a characteristic pattern.
In the control rats the food intake was greater during the first than the second 2 h period. Following (±)‐amphetamine 5 mg/kg s.c. 30 min before food for 7 days there was a reversal of this normal food pattern. The rats consumed much less during the first 2 h period but progressively more during the second 2 h period.
The first 2 h food intake remained low throughout the treatment period and there was no evidence of development of tolerance despite continuation of treatment.
The second 2 h food intake steadily increased, contributing to the appearance of tolerance when only total 4 h food intake was recorded.
On withdrawal of amphetamine, there was immediate recovery of the first 2 h food intake. The second 2 h food intake, though decreased, remained high compared to the pretreatment level and may be responsible for the production of the ‘rebound’ phenomenon following withdrawal of amphetamine.
When food intake in fasted male rats was recorded daily for two consecutive 2 h periods it revealed a characteristic pattern.
In the control rats the food intake was greater during the first than the second 2 h period. Following (±)‐amphetamine 5 mg/kg s.c. 30 min before food for 7 days there was a reversal of this normal food pattern. The rats consumed much less during the first 2 h period but progressively more during the second 2 h period.
The first 2 h food intake remained low throughout the treatment period and there was no evidence of development of tolerance despite continuation of treatment.
The second 2 h food intake steadily increased, contributing to the appearance of tolerance when only total 4 h food intake was recorded.
On withdrawal of amphetamine, there was immediate recovery of the first 2 h food intake. The second 2 h food intake, though decreased, remained high compared to the pretreatment level and may be responsible for the production of the ‘rebound’ phenomenon following withdrawal of amphetamine.
DOI: 10.1111/j.1476-5381.1973.tb08541.x
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