Article date: May 1973
By: R. T. BRITTAIN, J. B. FARMER, R. J. MARSHALL in Volume 48, Issue 1, pages 144-147
The pharmacological activities of the optical isomers of salbutamol have been examined. (–)‐Salbutamol was much more potent than (+)‐salbutamol on β‐adrenoceptors.
Both (–)‐ and (+)‐salbutamol showed high selectivity for β‐adrenoceptors in bronchial muscle compared to cardiac muscle, in this way resembling racemic salbutamol.
The use of isomeric activity ratio to detect differences between receptors was examined in the light of the results obtained with the isomers of salbutamol.
The pharmacological activities of the optical isomers of salbutamol have been examined. (–)‐Salbutamol was much more potent than (+)‐salbutamol on β‐adrenoceptors.
Both (–)‐ and (+)‐salbutamol showed high selectivity for β‐adrenoceptors in bronchial muscle compared to cardiac muscle, in this way resembling racemic salbutamol.
The use of isomeric activity ratio to detect differences between receptors was examined in the light of the results obtained with the isomers of salbutamol.
DOI: 10.1111/j.1476-5381.1973.tb08232.x
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