Article date: May 1973
By: I. R. INNES, R. MAILHOT in Volume 48, Issue 1, pages 139-143
Doses of cocaine which cause specific or unspecific supersensitivity in cat spleen did not alter the blocking effect of phenoxybenzamine on the responses of isolated cat spleen strips to noradrenaline.
The same doses of cocaine did not increase the protection of α‐adrenoceptors given by noradrenaline during a standard exposure to phenoxybenzamine.
It is concluded that cocaine does not change the affinity of the α‐adrenoceptor for noradrenaline, and therefore changes in affinity are not responsible for the potentiating action of cocaine.
Doses of cocaine which cause specific or unspecific supersensitivity in cat spleen did not alter the blocking effect of phenoxybenzamine on the responses of isolated cat spleen strips to noradrenaline.
The same doses of cocaine did not increase the protection of α‐adrenoceptors given by noradrenaline during a standard exposure to phenoxybenzamine.
It is concluded that cocaine does not change the affinity of the α‐adrenoceptor for noradrenaline, and therefore changes in affinity are not responsible for the potentiating action of cocaine.
DOI: 10.1111/j.1476-5381.1973.tb08231.x
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