Article date: October 1972
By: B. P. CURWAIN, PAMELA HOLTON in Volume 46, Issue 2, pages 225-233
. Isoprenaline (0·02 to 2·0 μg kg−1 min−1) inhibited gastric secretion in response to pentagastrin in both conscious and anaesthetized dogs and in response to feeding in conscious dogs.
. The inhibition was unaffected during cardiac β‐adrenoceptor blockade by propranolol.
. The inhibition was not due to decreased mucosal blood flow.
. This effect of isoprenaline is different from its effect on histamine‐induced gastric secretion.
. Noradrenaline (0·05–2·0 μg kg−1 min−1) also decreased gastric secretion but it was less effective than isoprenaline.
. The mechanism of action of noradrenaline is probably a decrease in mucosal blood flow.
. Isoprenaline (0·02 to 2·0 μg kg−1 min−1) inhibited gastric secretion in response to pentagastrin in both conscious and anaesthetized dogs and in response to feeding in conscious dogs.
. The inhibition was unaffected during cardiac β‐adrenoceptor blockade by propranolol.
. The inhibition was not due to decreased mucosal blood flow.
. This effect of isoprenaline is different from its effect on histamine‐induced gastric secretion.
. Noradrenaline (0·05–2·0 μg kg−1 min−1) also decreased gastric secretion but it was less effective than isoprenaline.
. The mechanism of action of noradrenaline is probably a decrease in mucosal blood flow.
DOI: 10.1111/j.1476-5381.1972.tb06867.x
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