Article date: October 1972
By: B. BERG, G. GRANERUS, MAJ‐BRITT JOHANSSON, H. WESTLING, T. WHITE in Volume 46, Issue 2, pages 270-280
. 14C‐l‐histidine was given i.v. to one normal subject and two patients with chronic myelocytic leukaemia. Urinary excretion of histamine and two of its metabolites methylhistamine and methylimidazoleacetic acid, total as well as 14C‐labelled, was measured, as well as blood 14C‐histamine. In addition the total urinary and pulmonary elimination of 14C was followed.
. Total 14C elimination was high during the first days, then declined slowly except for a plateau at the 10th–14th day in the two patients. There was a measurable elimination even after some months.
. 14C‐histamine appeared in the blood of the leukaemic patient, whereas in the normal subjects the values were hardly measurable.
. The leukaemic patients excreted much more of the two 14C‐labelled histamine metabolites than the normal subject. The difference in excretion of the 14C‐labelled metabolites was largest around the 12th day after the infusion of 14C‐l‐histidine.
. The results indicate that the leukaemic patients formed at least 20 times more histamine daily than the normal subject.
. 14C‐l‐histidine was given i.v. to one normal subject and two patients with chronic myelocytic leukaemia. Urinary excretion of histamine and two of its metabolites methylhistamine and methylimidazoleacetic acid, total as well as 14C‐labelled, was measured, as well as blood 14C‐histamine. In addition the total urinary and pulmonary elimination of 14C was followed.
. Total 14C elimination was high during the first days, then declined slowly except for a plateau at the 10th–14th day in the two patients. There was a measurable elimination even after some months.
. 14C‐histamine appeared in the blood of the leukaemic patient, whereas in the normal subjects the values were hardly measurable.
. The leukaemic patients excreted much more of the two 14C‐labelled histamine metabolites than the normal subject. The difference in excretion of the 14C‐labelled metabolites was largest around the 12th day after the infusion of 14C‐l‐histidine.
. The results indicate that the leukaemic patients formed at least 20 times more histamine daily than the normal subject.
DOI: 10.1111/j.1476-5381.1972.tb06872.x
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