Article date: September 1972
By: M. K. CHURCH, H. O. J. COLLIER, G. W. L. JAMES in Volume 46, Issue 1, pages 56-65
. A method for the measurement of anaphylactic bronchoconstriction in the rat is described.
. Dexamethasone inhibited this response in a dose‐related manner.
. Disodium cromoglycate antagonized the response. A bell‐shaped dose‐response curve was obtained with peak activity at 1 mg/kg i.v.
. Meclofenamate was not active when given alone or in combination with dexamethasone.
. Methysergide significantly inhibited the response. Mepyramine, atropine, propranolol and adrenalectomy did not significantly modify the response.
. The relationships of anaphylactic bronchoconstriction in the rat to anaphylactic bronchoconstriction in the guinea‐pig and to human asthma are discussed.
. A method for the measurement of anaphylactic bronchoconstriction in the rat is described.
. Dexamethasone inhibited this response in a dose‐related manner.
. Disodium cromoglycate antagonized the response. A bell‐shaped dose‐response curve was obtained with peak activity at 1 mg/kg i.v.
. Meclofenamate was not active when given alone or in combination with dexamethasone.
. Methysergide significantly inhibited the response. Mepyramine, atropine, propranolol and adrenalectomy did not significantly modify the response.
. The relationships of anaphylactic bronchoconstriction in the rat to anaphylactic bronchoconstriction in the guinea‐pig and to human asthma are discussed.
DOI: 10.1111/j.1476-5381.1972.tb06848.x
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