Renal excretion of metolazone, a new diuretic

Article date: July 1972

By: E. J. BELAIR, A. I. COHEN, J. YELNOSKY in Volume 45, Issue 3, pages 476-479

Metolazone, a new diuretic, was found to be excreted by glomerular filtration and renal tubular secretion.

The secretory mechanism was antagonized by probenecid but this did not affect the diuretic action of metolazone.

Metolazone, a new diuretic, was found to be excreted by glomerular filtration and renal tubular secretion.

The secretory mechanism was antagonized by probenecid but this did not affect the diuretic action of metolazone.

DOI: 10.1111/j.1476-5381.1972.tb08104.x

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