Article date: July 1972
By: J. ATKINSON, H. LADINSKY in Volume 45, Issue 3, pages 519-524
Investigations were carried out on the antagonism of the action of carbamylcholine chloride on the isolated fundus of the rat stomach by several tricyclic antidepressants.
The anticholinergic potency of the compounds was in the order: GP 45437>amitriptyline>protriptyline>desmethylimipramine>opipramol. All of the antagonists were less effective than atropine.
Statistical analysis was carried out to determine whether the theory of competitive antagonism would fit the data obtained.
Investigations were carried out on the antagonism of the action of carbamylcholine chloride on the isolated fundus of the rat stomach by several tricyclic antidepressants.
The anticholinergic potency of the compounds was in the order: GP 45437>amitriptyline>protriptyline>desmethylimipramine>opipramol. All of the antagonists were less effective than atropine.
Statistical analysis was carried out to determine whether the theory of competitive antagonism would fit the data obtained.
DOI: 10.1111/j.1476-5381.1972.tb08109.x
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