Interaction of 1‐methyl‐4‐phenylpyridinium ion and tyramine with a site putatively involved in the striatal vesicular release of dopamine

The neurotoxin MPP⁺ potently inhibited the striatal binding of [³H]‐tyramine, a putative marker for the vesicular transporter of dopamine, and provoked a massive in vivo release of striatal dopamine. Tetrabenazine, an established ligand for the vesicular catecholamine carrier, potently inhibited [³H]‐tyramine binding, tyramine‐provoked striatal efflux of dopamine and the fast component of MPP⁺‐induced dopamine release. It is concluded that MPP⁺ in the striatum, besides interacting with additional intracellular targets, avidly binds at a vesicular site functionally involved with the outward transport of dopamine.

DOI: 10.1111/j.1476-5381.1991.tb12470.x

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