Article date: December 1963
By: B. A. KOVACS, G. PELLETIER, B. ROSE in Volume 21, Issue 3, pages 419-426
A method for the extraction of an antihistamine‐like substance (or substances) from human tissues is described. The method has demonstrated the presence of this active principle(s) in a large variety of human tissues, so far without exception. The substance(s) has a wide range of activity in antagonizing the in vitro effects of histamine, 5‐hydroxytryptamine and bradykinin and the Schultz‐Dale reaction on the guinea‐pig ileum and rat uterus preparations.
DOI: 10.1111/j.1476-5381.1963.tb02009.x
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