Article date: December 1963
By: H. HERXHEIMER, E. STRESEMANN in Volume 21, Issue 3, pages 414-418
The dose/response curves for the protective effects of the new antihistamine compounds trimeprazine, 10‐(3‐diethylamino‐2‐methylpropyl)phenothiazine 1,1‐dioxide hydrochloride (oxomemazine hydrochloride), cyproheptadine, homochlorcyclizine and methotrimeprazine against the anaphylactic microshock of the guinea‐pig were similar to that of promethazine. The first three compounds, however, protected at lower doses than promethazine (5 to 10 μg/kg). The protective effect of cyproheptadine lasted longer than 24 hr.
DOI: 10.1111/j.1476-5381.1963.tb02008.x
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