OBSERVATIONS ON THE USE OF THE HEN AND RABBIT ISOLATED AURICLES FOR THE DETERMINATION OF INOTROPIC POTENCY

Article date: October 1963

By: J. A. LOCK in Volume 21, Issue 2, pages 393-401

The electrically driven, isolated auricles from the rabbit and the hen have been used to compare the inotropic potency of a bufodiene aglycone with ouabain. The results from the hen auricle permit conventional statistical treatment and show a good degree of reproducibility. Results of inotropic potencies and toxicity determinations on the two drugs are discussed.

DOI: 10.1111/j.1476-5381.1963.tb01537.x

View this article