ACTIONS OF BRETYLIUM AND GUANETHIDINE ON THE UPTAKE AND RELEASE OF [³H]‐NORADRENAUNE

The effect of bretylium and guanethidine has been studied on the uptake and the spontaneous and reserpine‐induced release of [³H]‐noradrenaline in the rat heart and in the splenic nerve endings of the cat. Bretylium and guanethidine inhibited the uptake by the heart of circulating [³H]‐noradrenaline. Bretylium blocked spontaneous and reserpine‐induced release of [³H]‐noradrenaline, while guanethidine caused release and partially antagonized the reserpine‐induced release. Both compounds produced a transient liberation of [³H]‐noradrenaline from splenic nerves, but blocked the release of the [³H]‐catechol amine following stimulation of the splenic nerve.

DOI: 10.1111/j.1476-5381.1962.tb01159.x

View this article

• Full article (html)
• Enhanced article (html)
• PDF
• References