Article date: December 1961
By: MARTA WEINSTOCK in Volume 17, Issue 3, pages 433-441
Evidence is presented that the receptors responsible for the mediation of analgesia by morphine‐like drugs are similar to those which are involved in the production of a reversible lenticular opacity. The activity of a number of compounds in mice on the lens was closely correlated with analgesic potency in this species. Stereospecificity for isomers with d configuration was demonstrated for both effects. Nalorphine only antagonized the lenticular opacity activity of those drugs the analgesic action of which it abolished.
DOI: 10.1111/j.1476-5381.1961.tb01130.x
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