Article date: December 1960
By: D. MACKAY, D. M. SHEPHERD in Volume 15, Issue 4, pages 552-556
A series of compounds has been examined for ability to inhibit histidine decarboxylase. Histidine analogues having substituents in the imidazole ring showed a wide variation in potency, but these were all much less active than α‐methyldopa [β‐(3,4‐dihydroxyphenyl)‐α‐methylalanine], the most potent known inhibitor of histidine decarboxylase. Some tentative conclusions are drawn regarding the relationship between chemical structure and inhibitory activity.
DOI: 10.1111/j.1476-5381.1960.tb00279.x
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