Article date: July 2010
By: Chadwick K. Mellen, Marjorie Ford, Joseph P. Rindone, in Volume 70, Issue 1, pages 139-142
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
AIM
To determine if high‐dose cranberry juice (240 ml twice daily) alters the pharmacodynamic action of warfarin.
METHODS
Ten male patients taking stable doses of warfarin were given cranberry juice at 240 ml twice daily for 7 days. Prothrombin times were drawn at baseline and days 2, 6 and 8 after administration of the juice. Prothrombin times were averaged for each day and mean times were compared from each study day to baseline using repeated measures anova.
RESULTS
There was no statistical difference between mean prothrombin time at baseline and any day tested during juice administration.
CONCLUSIONS
Cranberry juice (240 ml twice daily for 1 week) did not alter the pharmacodynamics of warfarin in patients.
DOI: 10.1111/j.1365-2125.2010.03674.x
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