Article date: January 2002
By: Christo T. Tzachev, Mariana Mandajieva, Evgeniy H. Minkov, Todor A. Popov, in Volume 53, Issue 1, pages 107-109
Aims To compare two xylometazoline 0.1% preparations: reference commercial solution (RS) and test mucoadhesive solution (TS).
Methods Twenty subjects with perennial allergic rhinitis (age range 18–69 years, 5 atopic, 7 men) applied randomly in turn TS and RS for 5 days in a double‐blind crossover clinical trial. Nasal airflow resistance (NAR), nasal symptoms (6 grade scoring), frequency of application (times/day), and side‐effects were recorded.
Results Mean ratio TS/RS of areas under the resistance/time curves for NAR ±90% CI: 3.56 ± 0.92; mean TS‐RS differences ±95% CI: for congestion: −1.12 ± 0.59, for frequency of application: −1.10 ± 0.20. Subjects experienced fewer side‐effects with TS.
Conclusions A mucoadhesive solution with a decongestant had a greater and longer lasting effect on nasal congestion in subjects with perennial allergic rhinitis than the commercially available decongestant solution. It also caused fewer side effects.
DOI: 10.1046/j.0306-5251.2001.01525.x
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