Article date: March 1978
By: YA Weiss, ME Safar, JP Lehner, JA Levenson, A Simon, JM Alexandre, in Volume 5, Issue 5, pages 457-460
1 Hepatic blood flow was determined before and during (+)‐ and (+/‐)‐ propranolol plasma concentration plateaus in 19 patients with suspected renal hypertension and normal liver function. 2 Hepatic blood flow significantly decreased (P less than 0.001) during (+/‐)‐propranolol administration and remained unchanged during (+)‐propranolol administration. 3 Hepatic extraction ratio was 74 +/− 1% (+/‐)‐ propranolol and 79 +/− 2% for (+)‐propranolol. 4 Total propranolol clearances were determined during the steady‐state achieved by a constant infusion. A highly significant positive relationship was observed (r = +0.86; P less than 0.01) between hepatic blood flow and (+)‐propranolol clearance. The slope of the curve was 1.05 +/− 0.27. 5 The result implies that the total clearance of (+)‐propranolol constitutes an accurate estimation of basal hepatic blood flow in subjects with normal liver function.
DOI: 10.1111/j.1365-2125.1978.tb01655.x
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