Article date: March 1978
By: W Esselinckx, PA Bacon, EF Ring, D Crooke, AJ Collins, D Demottaz, in Volume 5, Issue 5, pages 447-451
1 Three intra‐articular prednisolone analogues have been studied in a group of forty‐six rheumatoid arthritic subjects. Each compound was tested at 50 mg and 100 mg dose over 3 weeks. 2 The anti‐inflammatory effect was assessed by quantitative thermography. Systemic escape of the drug was monitored by plasma prednisolone and cortisol levels. 3 Both the systemic escape from the joint and the duration of effect on injected and uninjected knees were related to drug solubility. 4 Depression of plasma cortisol occurred with all three preparations and was most prolonged with the long‐acting preparation. 5 Increasing the dose from 50 mg to 100 mg increased the antiflammatory effect only with the soluble acetate preparation.
DOI: 10.1111/j.1365-2125.1978.tb01653.x
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