Article date: June 1989
By: EM Whitehead, GE Walters, PE Williams, GD Johnston, in Volume 27, Issue 6, pages 873-875
The pharmacokinetics of 1 mg, 2 mg and 4 mg of cilazaprilat administered intravenously were determined in a group of eight volunteers. The fall in plasma concentration was polyphasic. Elimination was predominantly by renal excretion of the unchanged drug. The mean renal clearance values following 1 mg, 2 mg and 4 mg doses were 5.3 +/‐ 0.5, 8.1 +/‐ 0.5, and 9.8 +/‐ 0.5 l h‐1 and plasma clearances were 7.8 +/‐ 0.5, 10.4 +/‐ 0.5 and 11.8 +/‐ 0.6 l h‐1, respectively. Thus, plasma and renal clearances were dose dependent. ACE inhibition was greater than 82% for the first 4 h and about 55% at 24 h, after all three doses. There were no significant haemodynamic effects at any dose.
DOI: 10.1111/j.1365-2125.1989.tb03453.x
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