Article date: March 1987
By: GG Birnie, KE McColl, GG Thompson, MR Moore, A Goldberg, MJ Brodie, in Volume 23, Issue 3, pages 358-361
Antipyrine kinetics following a single oral dose were obtained in porphyric patients in attack and in remission and in controls. The clearance of antipyrine was significantly lower during an acute porphyric attack (median: 0.34 ml min‐1 kg‐1; range: 0.1‐0.71, P less than 0.05) than in patients in remission (median: 0.53 ml min‐1 kg‐1; range: 0.28‐0.87) or controls (median: 0.52 ml min‐1 kg‐1; range: 0.32‐ 0.93). There was a significant negative correlation between weight‐ adjusted antipyrine clearance and the urinary excretion of the porphyrin precursors, delta‐aminolaevulinic acid (r = 0.86, P less than 0.001) and porphobilinogen (r = 0.82, P less than 0.002). These data suggest that the more severe the porphyric attack, the greater the impairment of hepatic monooxygenase activity.
DOI: 10.1111/j.1365-2125.1987.tb03059.x
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