Article date: March 1987
By: E Tanaka, A Ishikawa, A Ono, T Okamura, S Misawa, in Volume 23, Issue 3, pages 355-357
The metabolism of trimethadione (TMO) following oral administration (4 mg kg‐1) has been studied in 11 young male and 11 elderly male patients. The elimination half‐life (h) of TMO was 11.8 +/‐ 1.4 (mean +/‐ s.e. mean) in the young and 23.5 +/‐ 2.17 in the elderly (P less than 0.01). Total body clearance (1 h‐1 kg‐1) was 41.4 +/‐ 2.8 in the young and 29.0 +/‐ 2.4 in the elderly (P less than 0.01). The apparent volume of distribution (1 kg‐1) was 0.67 +/‐ 0.03 in the young and 0.65 +/‐ 0.04 in the elderly. Serum dimethadione (DMO)/TMO ratios at 4 h were 0.65 +/‐ 0.03 in the young and 0.46 +/‐ 0.03 in the elderly (P less than 0.01). These results suggest that N‐demethylation of TMO is inversely related to age.
DOI: 10.1111/j.1365-2125.1987.tb03058.x
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