Article date: February 1987
By: F Humphreys, S Shuster, in Volume 23, Issue 2, pages 234-236
The topical effect of the histamine H1‐receptor antagonist dimethindene maleate on the wealing response to intradermal histamine, compound 48/80 and house dust mite antigen was studied in 16 subjects using a double‐blind procedure. The mean reduction in weal area +/‐ s.e. mean was 44% +/‐ 13%, 43% +/‐ 13% and 31% +/‐ 13% for histamine, 48/80 and antigen respectively. We conclude that dimethindene maleate is a moderately potent H1‐receptor antagonist, and that the inhibition of the 48/80 and house dust mite induced weals is accounted for by the antihistaminic effect of dimethindene maleate.
DOI: 10.1111/j.1365-2125.1987.tb03035.x
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