Inhibition of antipyrine metabolism by interferon.

Antipyrine clearance was measured before and 1 day after administration of a single intramuscular dose of recombinant human leukocyte alpha A interferon. In the nine patients studied, antipyrine clearance was reduced after interferon from 0.49 (0.21‐1.13) ml kg‐1 min‐1 (median (range)) to 0.41 (0.20‐1.07) ml kg‐1 min‐1, P less than 0.01. In individual patients, the decrement in antipyrine clearance was variable, ranging from 5‐47% (median, 16%). This study provides the first direct evidence that interferon inhibits hepatic oxidative drug metabolism in humans and alerts clinicians to the possibility of potentially toxic drug‐drug interactions.

DOI: 10.1111/j.1365-2125.1986.tb02943.x

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