Article date: September 1986
By: KS Jayasinghe, CJ Roberts, AE Read, in Volume 22, Issue 3, pages 363-366
The extent of biliary excretion of paracetamol and its principal metabolites was studied in 10 healthy adults. Duodenal intubation was performed approximately 12 h after an oral dose of 1 g paracetamol. Duodenal fluid was aspirated following intravenous cholecystokinin, and urine was collected for 12 h after dosing. The mean concentration of the cysteine and glucuronide conjugates in the bile was 253.7 +/‐ 39.0 micrograms ml‐1 (s.e. mean) and 69.3 +/‐ 15.3 micrograms ml‐1, respectively. The mean recoveries of the cysteine and glucuronide conjugates in the bile were 6.0 +/‐ 1.5 mg and 1.2 +/‐ 0.41 mg, respectively. The bile is an important route of elimination for the cysteine conjugate and accounts for 19.4 +/‐ 4.4% of the total excretion of the metabolite. The fate of the biliary excreted conjugates is not known, and needs further investigation.
DOI: 10.1111/j.1365-2125.1986.tb02902.x
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