Article date: September 1986
By: JO Miners, RA Robson, DJ Birkett, in Volume 22, Issue 3, pages 359-362
Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug.
DOI: 10.1111/j.1365-2125.1986.tb02901.x
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